1 research outputs found
Inducible and combinatorial gene manipulation in mouse brain
We have deployed recombinant adeno-associated viruses equipped with
tetracycline-controlled genetic switches to manipulate gene expression in
mouse brain. Here, we show a combinatorial genetic approach for inducible,
cell type-specific gene expression and Cre/loxP mediated gene recombination in
different brain regions. Our chemical-genetic approach will help to
investigate ‘when’, ‘where’, and ‘how’ gene(s) control neuronal circuit
dynamics, and organize, for example, sensory signal processing, learning and
memory, and behavior